FIGURE

Fig. S1

ID

ZDB-FIG-080702-34

Publication

Lee et al., 2008 - Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye

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Fig. S1

Adult homozygous blowout mutant phenotype. Two to three percent of homozygous blw mutants is viable and reveals additional roles for Patched1 in the formation of the adult zebrafish. (A) Lateral and (B) dorsal views of a heterozygous and (C, D) homozygous blw mutant fish at 1.25 years of age. blw mutants are smaller than wild-type embryos and show defects in craniofacial and/or jaw development where the lower jaw protrudes away from face. Defects are variable, but nearly all homozygous blw mutants display some degree of jaw malformations. (D) Homozygous mutants also display varying degrees of body curvature.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ptch2^{tc294z/tc294z} ptch2^tc294z/+
Observed In:	mandibular arch skeleton reproductive process skeletal system development ventral mandibular arch whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 319(1), Lee, J., Willer, J.R., Willer, G.B., Smith, K., Gregg, R.G., and Gross, J.M., Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye, 10-22, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.