FIGURE

Fig. 7

ID

ZDB-FIG-080326-18

Publication

Scherz et al., 2008 - High-speed imaging of developing heart valves reveals interplay of morphogenesis and function

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Fig. 7

A balance of TXA2 and PGF2α signaling regulates myocardial cell shape. Zebrafish embryos were treated with 10 μM SQ29548 and 5 μM AL8810 (A,B), or 15 μM indomethacin (C,D), an inhibitor of Cox1 and Cox2, imaged with confocal (A-D), projections made (B,D) and the area (E) and circularity (F) measured and the 95% confidence interval calculated. Inhibition of both PGF2α and TXA2 signaling (A,B) or all Cox signaling (C,D) gave wild-type shape of the myocardium overlying the AVC (A,C) and wild-type myocardial area (B,D,E), although myocardial circularity was increased (F). (G) Table of the effects of inhibiting or activating different signaling pathways. (H) These findings suggest a model in which Cox2-derived TXA2 supports myocardial elongation, whereas PGF2α arising from Cox1 action or from the action of both Cox1 and Cox2 inhibits myocardial elongation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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