FIGURE

Fig. 9

ID

ZDB-FIG-080107-14

Publication

Yokogawa et al., 2007 - Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

Other Figures

All Figure Page

Back to All Figure Page

Fig. 9

Sleep-Wake Patterns in hcrtr¹⁶⁸ Mutants versus Wild-Type

Recordings were performed using the AFSRS over 48 h after 3 d of habituation. Data are plotted every 2 h. (Wild-type, n = 22; homozygous mutant, n = 17).

(A) Activity patterns. Note slightly increased activity (+20%) in mutant fish during the night.

(B) Percent sleep per hour. Note decreased sleep amounts (-30%) in mutant fish during the entire night.

(C) Mean wake bout length per hour (calculated as the mean period length of the non-sleep periods each hour) is similar in both genotypes.

(D) Mean sleep bout length per hour. Note dramatic decrease in sleep bout length (-65%) during the night in mutant animals.

(E) The number of sleep-wake transitions per hour increases dramatically in hcrtr¹⁶⁸ mutants during the night (+60%).

For overall means of these parameters across the dark and light periods, and during other light cycles, see Table 1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hcrtr2^{hu2098/hu2098}
Observed In:	circadian sleep/wake cycle, sleep circadian sleep/wake cycle, wakefulness
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Biol.