FIGURE

Fig. 3

ID

ZDB-FIG-071006-2

Publication

Arnaout et al., 2007 - Zebrafish model for human long QT syndrome

Other Figures

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Fig. 3

APs recorded from explanted embryonic zebrafish hearts. (a) (Upper) Representative spontaneous APs recorded from wild-type (WT) atrium (Left) and ventricle (Right) at 48 hpf. (Lower) Spontaneous APs recorded from kcnh2^s290 mutant atrium (Left). Recordings of transmembrane voltage (V _m) from mutant ventricle (Right) revealed marked membrane depolarization and the absence of action potentials. (b) V _m recorded from kcnh2^s290 mutant ventricle. Intracellular injection of hyperpolarizing current (-100 pA) caused membrane hyperpolarization and allowed for the generation of spontaneous APs.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kcnh6a^s290/s290
Observed In:	cardiac ventricle
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA