Fig. S1
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- ZDB-FIG-070822-69
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- Schoenebeck et al., 2007 - Vessel and blood specification override cardiac potential in anterior mesoderm
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Efficient Differentiation of Rostral Cardiomyocytes in clo Mutant Embryos Requires Hand2 (A-L) Two-color fluorescent in situ hybridization at the 20 somite stage, dorsal views, anterior to the top. Scale bar represents 100 μm. (A-D) Overlays of cmlc2 (E-H) and nkx2.5 (I-L) expression. Wild-type embryos (A,E,I) exhibit efficient myocardial differentiation of nkx2.5- expressing cells, in contrast to the limited differentiation observed in han mutants (B,F,J). Examination of han;clo double mutants (D,H,L) demonstrates that ectopic myocardial differentiation in nkx2.5-expressing rostral ALPM (arrows, C,D,G,K,L), as observed in clo mutants (C,G,K), also requires Hand2 function. Therefore, cmlc2 expression in han;clo double mutants (H) appears similar to cmlc2 expression in han mutants (F). |
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| Stage: | 20-25 somites |
Reprinted from Developmental Cell, 13(2), Schoenebeck, J.J., Keegan, B.R., and Yelon, D., Vessel and blood specification override cardiac potential in anterior mesoderm, 254-267, Copyright (2007) with permission from Elsevier. Full text @ Dev. Cell