FIGURE

Fig. 5

ID

ZDB-FIG-070619-12

Publication

Shu et al., 2007 - Na,K-ATPase α2 and Ncx4a regulate zebrafish left-right patterning

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Fig. 5

Ncx4a is required for heart and gut LR patterning in zebrafish. (A-F) Expression pattern of the genes encoding Na,K-ATPase α2 and Ncx4a. Transcripts encoding Na,K-ATPase α2 (A) and Ncx4a (D) are detected prior to the mid-blastula stage. By the 10-somite stage, Na,K-ATPase α2 (B) and Ncx4a (E) are expressed in a broad range of tissues including Kupffer's vesicle (kv, arrow). By the 24-somite stage, Na,K-ATPase α2 is expressed predominantly in the somites (C), whereas Ncx4a remains ubiquitous (F). (G) Bar chart of the percentage of embryos exhibiting heart and/or gut laterality defects.

Expression Data

Genes:	atp1a2a slc8a4a
Fish:	TL
Anatomical Terms:	Kupffer's vesicle somite unspecified
Stage Range:	1k-cell to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + MO1-atp1a2a + MO1-slc8a4a
Knockdown Reagents:	MO1-atp1a2a MO1-slc8a4a
Observed In:	determination of left/right symmetry
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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