Fig. 7
- ID
- ZDB-FIG-061218-8
- Publication
- Smith et al., 2006 - Inhibition of BMP signaling during zebrafish fin regeneration disrupts fin growth and scleroblast differentiation and function
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(A–F) In situ hybridization on longitudinal sections of 4 dpa fin regenerates showing sox9a (A, B), sox9b (C, D) and col2a1 (E, F) expression. (A) sox9a is expressed in the mesenchyme of the blastema, in a few cells of the basal layer of the epidermis (arrow) and in newly differentiating scleroblasts (asterisk). (B) 1 day following injection of chordin, sox9a expression is downregulated. (C) sox9b is expressed in cells of the basal epidermal layer in the distal part of the regenerate (arrow). (D) sox9b expression is unaffected in chordin-injected rays at 1 dpi. (E) col2a1 is strongly expressed in the scleroblasts, in cells surrounding the actinotrichia (white arrowheads), the mesenchyme of the blastema and faintly in the basal epidermal layer (arrow). (F) col2a1 expression is partially downregulated in the scleroblasts and mesenchyme following chordin injection but is still present in cells surrounding actinotrichia (white arrowheads). (G) Alcian blue staining shows that the regenerate is devoid of any cartilage cells although staining is observed in the lepidotrichial material and in a few mucous cells (arrows). ble, basal layer of the epidermis, b, blastema; s, scleroblasts. Distal part of the regenerate is to the right. Scale bars: (A–G) = 25 μm. |
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| Stage: | Adult |
Reprinted from Developmental Biology, 299(2), Smith, A., Avaron, F., Guay, D., Padhi, B.K., and Akimenko, M.A., Inhibition of BMP signaling during zebrafish fin regeneration disrupts fin growth and scleroblast differentiation and function, 438-454, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.