Fig. 4
- ID
- ZDB-FIG-060818-10
- Publication
- Jasuja et al., 2006 - bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis
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Altered expression patterns of chordin and gata2 in embryos dorsalized by knockdown of bmp1 and tll1. (A–D) Chordin localization is shown at 6 hpf for (A) wild type embryo; (B) bmp1 morphant, in which there is a lateral expansion of chordin expression; (C) tll1 morphant, which does not have a clearly expanded chordin expression domain; and (D) bmp1/tll1 double morphant, showing massive lateral expansion of chordin expression. (E–H) Chordin localization is shown at 9 hpf for (E) wild type embryos; (F) bmp1 morphant, in which chordin expression is expanded; (G) tll1 morphant, showing expanded chordin expression; and (H) bmp1/tll1 double morphant. The notochord is delineated by strong chordin signal in E–H, and by arrows in H. Note the broadening of the notochord observed in the dorsalized morphants. (I–L) gata2 localization is shown at 9 hpf. Note the greatly reduced gata2 expression domain in the bmp1/tll1 double morphant compared to wild type (gata2 domain margins marked by arrows in I and L). (A–D, I–L) Animal pole views, dorsal to the right. (E–H) Dorsal views, G and H slightly tilted to the right. |
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| Stage Range: | Shield to 90%-epiboly |
Reprinted from Mechanisms of Development, 123(7), Jasuja, R., Voss, N., Ge, G., Hoffman, G.G., Lyman-Gingerich, J., Pelegri, F., and Greenspan, D.S., bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis, 548-558, Copyright (2006) with permission from Elsevier. Full text @ Mech. Dev.