FIGURE

Fig. 5

ID

ZDB-FIG-060621-5

Publication

Ellertsdottir et al., 2006 - A mutation in the zebrafish Na,K-ATPase subunit atp1a1a.1 provides genetic evidence that the sodium potassium pump contributes to left-right asymmetry downstream or in parallel to nodal flow

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Fig. 5

Phenocopy of the m883 phenotype with the Na,K-ATPase pump blocker ouabain. A,B: When wild-type embryos were incubated from the 1,000-cell stage onward with 3 mM ouabain, the morphology of embryos resembled m883 mutant embryos. C,D: In the ouabain-treated embryos, the expression of pitx2 reveals isomerism in the heart anlage at the 26-somite stage. E,F: The expression of pitx2 is found bilateral in the lateral plate mesoderm in the ouabain-treated embryos, similar to embryos mutant for the Na, K ATPase alpha1a.1 subunit. A,B,E,F: Anterior to the left; (A, B) lateral and (E, F) dorsal views. C,D: Anterior to the top, dorsal view.

Expression Data

Gene:	pitx2
Fish:	WT
Condition:	chemical treatment: ouabain
Anatomical Terms:	heart rudiment lateral plate mesoderm
Stage:	26+ somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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