FIGURE

Fig. 4

ID

ZDB-FIG-051214-22

Publication

Whitlock et al., 2005 - A role for foxd3 and sox10 in the differentiation of gonadotropin-releasing hormone (GnRH) cells in the zebrafish Danio rerio

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Role of foxd3 and sox10 in the development of gnrh3 cells in the terminal nerve. Whole mounts showing gnrh3 expression (arrows) at 35±1 hpf in foxd3+sox10 mismatch control (A), foxd3 MO (B), sox10 MO (C) and foxd3+sox10 MO (D-F) morphant animals. Knockdown of either gene, or of both genes together, caused a significant decrease in the number of cells expressing GnRH3 (see Table 1). Knockdown of both Foxd3 and Sox10 proteins resulted in a total loss of gnrh3 cells (D), or a partial loss of gnrh3 cells either associated with the olfactory placode (E, arrow), or displaced dorsally (F, arrows). Purple outline indicates the olfactory placodes. (A-E) Ventral views with anterior at the top; (F) frontal view with dorsal at the top. Scale bar: 80 µm.

Expression Data

Gene:	gnrh3
Fish:	WT + MO1-sox10 WT + MO2-foxd3 WT + MO1-sox10 + MO2-foxd3
Knockdown Reagents:	MO1-sox10 MO2-foxd3
Anatomical Terms:	telencephalon terminal nerve
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development