FIGURE

Fig. 4

ID

ZDB-FIG-051102-4

Publication

Kaji et al., 2004 - dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula

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Fig. 4

HuC expression in embryos injected with dlx3b-ATG-MO and dlx4b-ATG-MO and EnR-dlx3bhd mRNA at 3-somite stage. (A, C, E, G, I) Dorsal views, anterior is to the top. (B, D, F, H, J) Anterior views. (A and B) Wild-type embryos. (C and D) 8 ng dlx3b-MO- and 8 ng dlx4b-MO-injected embryos. (E and F) 16 ng dlx3b-MO- and 16 ng dlx4b-MO-injected embryos. (G and H) 60 pg EnR-dlx3bhd mRNA-injected embryos. (I and J) 120 pg EnR-dlx3bhd mRNA-injected embryos. (A–F) and (G–J) show that the expression of HuC, which is expressed in RB neurons in the trunk (rb) and neurons in trigeminal placodes in the head (tg), is gradually reduced as the concentration of MOs and EnR-dlx3bhd mRNA are increased. In contrast, primary motor neurons (arrowhead) and anterior lateral hindbrain interneurons (li) and anterior medial hindbrain interneurons (mi) are not changed.

Expression Data

Gene:	elavl3
Fish:	AB/TL AB/TL + MO2-dlx4b + MO3-dlx3b
Knockdown Reagents:	MO2-dlx4b MO3-dlx3b
Anatomical Terms:	hindbrain neural plate primary motor neuron Rohon-Beard neuron
Stage:	1-4 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TL + MO2-dlx4b + MO3-dlx3b
Knockdown Reagents:	MO2-dlx4b MO3-dlx3b
Observed In:	Rohon-Beard neuron trigeminal ganglion neuron
Stage:	1-4 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 276(2), Kaji, T., and Artinger, K.B., dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula, 523-540, Copyright (2004) with permission from Elsevier. Full text @ Dev. Biol.