Fig. 1
- ID
- ZDB-FIG-050128-9
- Publication
- Hughes et al., 2004 - Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio
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Whole mount in situ hybridization analysis of otop1 mRNA expression. (A) Lateral view of a 24 hpf embryo showing significant expression of otop1 in the ventral half of the developing otic vesicle. (B) Dorsal view at 24 hpf showing otop1 expression. (C) Lateral view of 3 dpf larva showing otop1 mRNA expression in the sensory epithelium. (D) Four-μm plastic section of the otocyst of a 3 dpf fish (dorsal is up, lateral to the right) stained with Richardson′s stain (100×). Pale apical cells with round nuclei (arrow) are hair cells. Cells with elongated, densely staining nuclei (arrowheads) are precursor cells within the macular growth zone. (E) Similar 4 μm plastic section of a 3 dpf fish showing otop1 mRNA localized to the luminal cells of the otocyst and adjacent cells in the monolayer, consistent with expression in the mature and developing hair cells (100x). (F) Lateral view of a 5 dpf larva showing otop1 expression along the entire length of the animal in the anterior and lateral line organs (arrowheads). Scale bars: A, 50 μm; B–C, 250 μm; D–E, 10 μm; and F, 50 μm. |
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| Stage Range: | Prim-5 to Day 5 |
Reprinted from Developmental Biology, 276(2), Hughes, I., Blasiole, B., Huss, D., Warchol, M.E., Rath, N.P., Hurle, B., Ignatova, E., David Dickman, J., Thalmann, R., Levenson, R., and Ornitz, D.M., Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio, 391-402, Copyright (2004) with permission from Elsevier. Full text @ Dev. Biol.