CRISPR

CRISPR1-serpini1

ID
ZDB-CRISPR-210824-1
Name
CRISPR1-serpini1
Previous Names
None
Target
Sequence
5' - GGCAAGAGGAACCTCCTGA - 3'
ZFIN BLAST NCBI BLAST Ensembl
Disclaimer
Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.
Note
The PAM site was "CGG" at the 3' end.
Genome Resources
None
Target Location
Constructs
No data available
Genomic Features
Genomic Feature Affected Genomic Regions
zf3500 serpine1
zf3527 serpini1
Expression
Gene expression in Wild Types + CRISPR1-serpini1
No data available
Phenotype
Phenotype resulting from CRISPR1-serpini1
No data available
Phenotype of all Fish created by or utilizing CRISPR1-serpini1
Phenotype Fish Conditions Figures
whole organism capn1b expression increased amount, abnormal serpine1zf3500/zf3500 (AB) standard conditions Fig. 4 from Han et al., 2020
whole organism serpine1 expression decreased amount, abnormal serpine1zf3500/zf3500 (AB) standard conditions Fig. 1 from Han et al., 2020
whole organism plat expression decreased amount, abnormal serpine1zf3500/zf3500 (AB) standard conditions Fig. 1 from Han et al., 2020
whole organism thigmotaxis increased process quality, abnormal serpine1zf3500/zf3500 (AB) control Fig. 2 from Han et al., 2020
whole organism rgs2 expression decreased amount, abnormal serpine1zf3500/zf3500 (AB) standard conditions Fig. 4 from Han et al., 2020
whole organism serpini1 expression decreased amount, abnormal serpine1zf3500/zf3500 (AB) standard conditions Fig. 1 from Han et al., 2020
embryo development disrupted, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 2 with image from Han et al., 2021
locomotory behavior decreased occurrence, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 3 with image from Han et al., 2021
eye decreased size, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 2 with image from Han et al., 2021
pericardium edematous, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 2 with image from Han et al., 2021
eye deformed, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 2 with image from Han et al., 2021
heart apoptotic process increased occurrence, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 5 with image from Han et al., 2021
whole organism decreased life span, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 2 with image from Han et al., 2021
brain deformed, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 2 with image from Han et al., 2021
whole organism superoxide dismutase activity decreased process quality, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 5 with image from Han et al., 2021
hatching decreased rate, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 2 with image from Han et al., 2021
whole organism catalase activity decreased process quality, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 5 with image from Han et al., 2021
whole organism malonaldehyde increased amount, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 5 with image from Han et al., 2021
spinal cord apoptotic process increased occurrence, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 5 with image from Han et al., 2021
brain apoptotic process increased occurrence, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 5 with image from Han et al., 2021
spinal cord deformed, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 2 with image from Han et al., 2021
brain decreased size, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 2 with image from Han et al., 2021
whole organism dead, abnormal serpini1zf3527/zf3527 chemical treatment by environment: cobalt dichloride FIGURE 2 with image from Han et al., 2021
primary motor neuron axon decreased length, abnormal serpine1zf3500/zf3500; fdu101Tg (AB) standard conditions Fig. 3 from Han et al., 2020
diencephalon neuron decreased amount, abnormal serpini1zf3527/zf3527; fdu101Tg chemical treatment by environment: cobalt dichloride FIGURE 3 with image from Han et al., 2021
brain vasculature decreased branchiness, abnormal serpini1zf3527/zf3527; y1Tg chemical treatment by environment: cobalt dichloride FIGURE 4 with image from Han et al., 2021
brain vasculature malformed, exacerbated serpini1zf3527/zf3527; y1Tg chemical treatment by environment: cobalt dichloride FIGURE 4 with image from Han et al., 2021
Citations
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