Genomic Feature
dty40
- ID
- ZDB-ALT-980203-1265
- Name
- dty40
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| This allele contains an Asp(447)-> Glu exchange caused by a GAT->GAA mutation. ... | Kramer et al., 2002 |
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 14: 26467826 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Asp>Glu at position 447 (1)
- Flanking Sequence
-
GCCTTGCGAATAACAGGATTAGACAACATAGCAATTAAAAAGATTCTCATAAAACTAGGAAACTGCAATTGCATTTTTCAACTGGTGTAAAGTGAAGTAGAGATACATGAAAGCATGTCAATGTCATCTACTAGATTACCTACAGTTAGAGAAAATCAGTCATACAAGCATCATTGTAAAACAACTGTATGCAAAAAAACAACAAAACAAAACATGAAGTCAATTGCTAAAGCAGTAGTTAGTCCATTTTGTGTCACTGCCTAGAATTTTCCTATGCTAGATGTGCTTGTAGCCCCAGTTCATCTTCTCGTTCTGACTGCTGCAGGATTTGGTGGCATTCTCCAGGTTGTGTAAACAGTTCAGCCCTTAAGACCTCCTATTCTTTCAAAAGTGAAGAAAGAAAATAAGAAGAAGAAAACAAAGGCTCCTCCCAGGTCAGCCCATCATTACGAGACAGAAGAGATGGGGTTCAGAGGGGAACCCATTTGTGTTAGAACTTT
A/T TCCAGCCATTGCAGGGGGCCGTGGAGATGCACTTCTATCCAGCAGGGGGTGCTTGTCACATCTTGTCTGTGGTACTCGGCACCCCAACCCTTGAATAGAAAGAAATAAAGAAAAAAGTTGAAGATTAAACATGGATGGATGGAATTATATTCATATCACTTGGTTCTTGATCTAAAACTCAGAGCAACAAGTGTATATTACTAATAATAAATCAATTGACTGATTATTTTATTATATTTTTTCTGAATTTGTACTTCTAATGTTAAGATAAAAATCATTGAAAAGTCTGACGATAAAACATTTTTAAAAGCAAAGGAAAGTAAACATTTACAACATCAATAGTCATTTTTGGTGTTGCTAATAAAAATAGTTGTATTCGACCTTAATTTACACTAGTAAGTTGAATATTACAGTTTACTGTGGCCACAATGTCACTATCAGCCAAAAAAGATACATAAAGATGCATTTGCACATGACACTTATTTGCAAACAATTCCAAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| smad5dty40/dty40 | Homozygous | ♀+/- ♂+/- | 2 figures  from 2 publications | 4 figures from 2 publications | |
| smad5dty40/dty40 (TU) | Homozygous | ♀+/- ♂+/- | 6 figures from 3 publications | 2 figures from Mullins et al., 1996 | |
| smad5dty40/+ | Heterozygous | Unknown | Fig. 3 from McReynolds et al., 2008 | ||
| smad5dty40/+ | Heterozygous | ♀+/- ♂+/- | 5 figures from 2 publications | Fig. 2 from Yang et al., 2011 | |
| smad5dty40/+ (AB) | Heterozygous | Unknown | |||
| smad5dty40/+ (TU) | Heterozygous | ♀+/- ♂+/- | Fig. 2 from Mullins et al., 1996 | ||
| smad5dty40/+; zf540Tg | Complex |
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Supplemental Information
- Genotyping protocol
- dty40.pdf
- Yang, Y., and Thorpe, C. (2011) BMP and non-canonical Wnt signaling are required for inhibition of secondary tail formation in zebrafish. Development (Cambridge, England). 138(12):2601-2611
- McReynolds, L.J., Tucker, J., Mullins, C.M.C., and Evans, T. (2008) Regulation of hematopoiesis by the BMP signaling pathway in adult zebrafish. Experimental hematology. 36(12):1604-1615
- McReynolds, L.J., Gupta, S., Figueroa, M.E., Mullins, M.C., and Evans, T. (2007) Smad1 and Smad5 differentially regulate embryonic hematopoiesis. Blood. 110(12):3881-3890
- Kramer, C., Mayr, T., Nowak, M., Schumacher, J., Runke, G., Bauer, H., Wagner, D., Schmid, B., Imai, Y., Talbot, W., Mullins, M., and Hammerschmidt, M. (2002) Maternally supplied smad5 is required for ventral specification in zebrafish embryos prior to zygotic bmp signaling. Developmental Biology. 250(2):263-279
- Willot, V., Mathieu, J., Lu, Y., Schmid, B., Sidi, S., Yan, Y.-L., Postlethwait, J.H., Mullins, M., Rosa, F., and Peyriéras, N. (2002) Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula. Developmental Biology. 241(1):59-78
- Connors, S.A., Trout, J., Ekker, M., and Mullins, M.C. (1999) The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo. Development (Cambridge, England). 126(14):3119-3130
- Chen, J.-N., van Eeden, F.J.M., Warren, K.S., Chin, A., Nüsslein-Volhard, C., Haffter, P., and Fishman, M.C. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development (Cambridge, England). 124(21):4373-4382
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
- Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., and Nüsslein-Volhard, C. (1996) Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development (Cambridge, England). 123:81-93
- van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki-, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development (Cambridge, England). 123:153-164
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