Genomic Feature
cri2
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 5: 33282763 - 33282785 (GRCz11) (1) Details
- Nucleotide change
- ACCAGAAACCAGGACGAAAGGAC/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 23 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
GAAACGTAGAAAGTGGAAGTTGGAGCTGATCAGTGAACTTCAGAGTCTGACGACTTCAGTGCCAATCCCACTGCCTGTAGAGTGAGTCTCTGTGCCTTCCGTTCCTCCATGTGGAGGTAATACACAAACTTATAATGATTTGATGTTATAATGAAGTAACAATGTTATGTATGTGTGAGGCAGTACTATGGAAATCAAGCAGCTGGAGTACAGGCGTGTGAAGGTCCGTGGACATTTTGATCACTCTAAGGAGCTGTATATTTTGCCCCGTTCCCCTGTGGACCCTGAGAGAGAGGCTCGAGAGGCAGGGAGGATATCCTCCAGTGGTGAAAGTGGAGCAAATGTTATTACACCCTTTTTCTGCACTGATCTGGGGTACAAACACACACTATTAGAATTTTACTTGGATTATGCATATACTTGATTTGCAACTCACTGCAGCACATTTTTAGGATCACTATCTTGGTGAACAGAGGTTATGTACCCAAAAACAAGATCAA
ACCAGAAACCAGGACGAAAGGAC/- AGGTAATATAGTGCTTTTCTTAATTTATTTTTAGATCAAATCTAGGCGTAAATATTGCCAATTAATTTTTTTTCTTTGTTAGTCCAAACTGGCTTATATACACACAAGGTTATGCAAATTAGCAGTCAGATGTAACATTTAAAAAAAACAAAAAAAACAAAAACATGAATTTTGTATTTACTAATGAAATCTATCAACTGGTGACATATGGACACTTCACATGCAGTGTATACCCTTAATTCTTGACTTTTTAATGCTCTTATTGGTTGAGTTTATATTTTATAAAAGGTGATTGAGGATGTGGATCTTGTTGGTGTTGTGCGTTTAACTGAACAACGGAAACCATTTGTCCCTGAAAACAATGTGGAGGCAAACAGATGGCACTATCGTGACCTGGAGGCCATGGCTAAGGTCACTGGTGCCGAAGAGATCTTCATTGATGCTGTGCTTGGTTAAGTGCTTTTCCCAATATCCTGACTTTTCAAGAATATTTAGAACAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| surf1cri2/cri2 | Homozygous | Unknown | 8 figures  from 2 publications |
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Supplemental Information
- Genotyping protocol
- None
- Haroon, S., Yoon, H., Seiler, C., Osei-Frimpong, B., He, J., Nair, R.M., Mathew, N.D., Burg, L., Kose, M., Venkata, C., Anderson, V.E., Nakamaru-Ogiso, E., Falk, M.J. (2023) N-Acetylcysteine and cysteamine bitartrate prevent azide-induced neuromuscular decompensation by restoring glutathione balance in two novel surf1-/- zebrafish deletion models of Leigh syndrome. Human molecular genetics. 32(12):1988-2004
- Sharma, S., Magnitsky, S., Reesey, E., Schwartz, M., Haroon, S., Lavorato, M., Chan, S., Xiao, R., Wilkins, B.J., Martinez, D., Seiler, C., Falk, M.J. (2023) Novel Development of Magnetic Resonance Imaging to Quantify the Structural Anatomic Growth of Diverse Organs in Adult and Mutant Zebrafish. Zebrafish. 21(1):28-38
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