Gene
surf1
- ID
- ZDB-GENE-041108-2
- Name
- SURF1 cytochrome c oxidase assembly factor
- Symbol
- surf1 Nomenclature History
- Previous Names
-
- im:6898613
- zgc:158646
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables cytochrome-c oxidase activity. Acts upstream of or within embryonic organ development and spinal cord motor neuron differentiation. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4K; Leigh disease; and cytochrome-c oxidase deficiency disease. Orthologous to human SURF1 (SURF1 cytochrome c oxidase assembly factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898613 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cri1 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| cri2 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la029083Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mn123 | Allele with one deletion | Unknown | Frameshift | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 4K | Alliance | Charcot-Marie-Tooth disease, type 4K | 616684 |
| mitochondrial complex IV deficiency nuclear type 1 | Alliance | Mitochondrial complex IV deficiency, nuclear type 1 | 220110 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Surfeit locus 1/4 | Surfeit locus 1/Shy1 |
|---|---|---|---|
|
UniProtKB:A0A8M3B2I7
|
190 | ||
|
UniProtKB:A1L248
|
309 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-278C20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-226M8 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6898613 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:158646 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191437 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080173 (1) | 1044 nt | ||
| Genomic | GenBank:CR382323 (1) | 143411 nt | ||
| Polypeptide | UniProtKB:A1L248 (1) | 309 aa |
- Haroon, S., Yoon, H., Seiler, C., Osei-Frimpong, B., He, J., Nair, R.M., Mathew, N.D., Burg, L., Kose, M., Venkata, C., Anderson, V.E., Nakamaru-Ogiso, E., Falk, M.J. (2023) N-Acetylcysteine and cysteamine bitartrate prevent azide-induced neuromuscular decompensation by restoring glutathione balance in two novel surf1-/- zebrafish deletion models of Leigh syndrome. Human molecular genetics. 32(12):1988-2004
- Sharma, S., Magnitsky, S., Reesey, E., Schwartz, M., Haroon, S., Lavorato, M., Chan, S., Xiao, R., Wilkins, B.J., Martinez, D., Seiler, C., Falk, M.J. (2023) Novel Development of Magnetic Resonance Imaging to Quantify the Structural Anatomic Growth of Diverse Organs in Adult and Mutant Zebrafish. Zebrafish. 21(1):28-38
- Sabharwal, A., Campbell, J.M., Schwab, T.L., WareJoncas, Z., Wishman, M.D., Ata, H., Liu, W., Ichino, N., Hunter, D.E., Bergren, J.D., Urban, M.D., Urban, R.M., Holmberg, S.R., Kar, B., Cook, A., Ding, Y., Xu, X., Clark, K.J., Ekker, S.C. (2022) A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish. Genes. 13(8):
- Ata, H., Ekstrom, T.L., Martínez-Gálvez, G., Mann, C.M., Dvornikov, A.V., Schaefbauer, K.J., Ma, A.C., Dobbs, D., Clark, K.J., Ekker, S.C. (2018) Robust Activation of Microhomology-mediated End Joining for Precision Gene Editing Applications. PLoS Genetics. 14:e1007652
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hensley, M.R., Cui, Z., Chua, R.F., Simpson, S., Shammas, N.L., Yang, J.Y., Leung, Y.F., Zhang, G. (2016) Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Scientific Reports. 6:27816
- Ma, A.C., McNulty, M.S., Tanya, P.L., Jarryd, C.M., Martínez-Gálvez, G., Argue, D.P., Lee, H.B., Urban, M.D., Bullard, C.E., Blackburn, P.R., Man, T.K., Clark, K.J., Ekker, S.C. (2016) FusX: A rapid one-step TALE assembly system for genome science. Human gene therapy. 27(6):451-63
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Ng, Y.K., Wu, W., and Zhang, L. (2009) Positive correlation between gene coexpression and positional clustering in the zebrafish genome. BMC Genomics. 10:42
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