Genomic Feature
uab118
- ID
- ZDB-ALT-180420-2
- Name
- uab118
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Gorelick Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 20: 26377842 - 26377845 (GRCz11) (1) Details
- Nucleotide change
- CGGC/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp deleted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TTGCGTAAACCGATTCCAACAAACAATTTAAGTTTCAAAGCTAATCCTTCCTCCATTTAAGTTAAAGAAATGAAGTATTTATTTAACTCATTACTTTCAACACTGAGTTCAAAACTCTTTTCAAATGCGTAGAATTACCTTTCAGTATGTTTTAAGTCAGCTACAGTCATTTCATTTGATAAAGTTGACTGTTGGGTTTTACAGTGTATTAACAAAGCTGTGATTTGTTTTTGTTTTTTATTTGCAGCCGCGTCACATCCCTGCTGATATTCAGAACAACAAGACTGCATGTAAAACAGGCTGGTCACCTTGAATGCTTCTCTTGAAGAAAGCTTTGCATCCCTCACACGACCAGACTCCGTAATGATATCCAGAGGCGTAGTCACTGCACACCGCACAGAAGCGAGTCTCTTTCCCTGAATCAAAGCCTCCAGCCGCTCTGGATCCAGTGTACAACTCCTGCCTGTCAGTGGCACTGCACAGCTCCTCACACAGGCCCA
CGGC/- TGCCTGCTGAGAGGACACCACACTGGACCTGCACAAAAACAGAGGTGAACAGTCAATACACTAGATGTTACACTTCATATAAATAATTATTAAAGCAATAGTATTTAAAGTCTATATGAACATGAGGAGGGTGGCGTTTTATTTTAGCACTCCTCCTAGTCATCTCTCACATCTCAAACTAGATTATAATTGTAAATCAGGTTATAAATAAGAGGAAATAAGCATGCGCAAAAAATAGTAACAGCGTTCGCATGGGTTTCCTCCGGGTGCTCTGGTTTCCCCCACAGTCCAAAGACATGCAGTACAGGTGAATTGGGTTGGCTACATTGTCCATAGTATATGAGTGTGTGTGGATGTTTCCCAAAGATGGGTTGCGGCTGGAAGGGTATCCGCTGCGTAAAAACATGCTGGACAAGTTGGCGGTTCATTCCGCTGTGGCAACCCCGGATTAATAAAGGGACTAAGCTGACAAGAAAATGAATGAATGAATAAAAAAAATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| esr1uab118/+; c262Tg/c262Tg | Complex | Fig. S2 from Romano et al., 2017 | |||
| esr1uab118/uab118; c262Tg/c262Tg | Complex | Fig. 3 from Romano et al., 2017 | Fig. S2 from Romano et al., 2017 | ||
| esr1uab118/uab118; c262Tg/c262Tg | Complex | Fig. S5 from Romano et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Souder, J.P., Gorelick, D.A. (2019) ahr2, but not ahr1a or ahr1b, is required for craniofacial and fin development and TCDD-dependent cardiotoxicity in zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 170(1):25-44
- Romano, S.N., Edwards, H.E., Souder, J.P., Ryan, K.J., Cui, X., Gorelick, D.A. (2017) G protein-coupled estrogen receptor regulates embryonic heart rate in zebrafish. PLoS Genetics. 13:e1007069
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