Gene
esr1
- ID
- ZDB-GENE-020806-5
- Name
- estrogen receptor 1
- Symbol
- esr1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables nuclear estrogen receptor activity; nuclear receptor activity; and steroid binding activity. Acts upstream of or within several processes, including cellular response to estrogen stimulus; posterior lateral line neuromast primordium migration; and response to estradiol. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including diencephalon; head; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 50 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu209 (1 image)
- af349412 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb248 | Allele with one delins | Exon 4 | Unknown | CRISPR | |
| sa29373 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uab118 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| uab119 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ulg078 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| umo10 | Allele with one deletion | Exon 2 | Premature Stop | CRISPR | |
| zf2164 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | TALEN |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Estrogen receptor | Estrogen receptor, N-terminal | Estrogen receptor/oestrogen-related receptor | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:P57717
|
569 | |||||||||
|
UniProtKB:A0A8M3B0Y2
|
613 |
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Interactions and Pathways
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-109I14 | ZFIN Curated Data | |
| Contained in | BAC | CH73-192G21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-87A14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-147O6 | ZFIN Curated Data | |
| Encodes | EST | af349412 | Bertrand et al., 2007 | |
| Encodes | EST | eu209 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193559 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152959 (1) | 3439 nt | ||
| Genomic | GenBank:BX936462 (1) | 196432 nt | ||
| Polypeptide | UniProtKB:A0A8M3B0Y2 (1) | 613 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | ESR1 | 6 | Conserved genome location (synteny) (1) Phylogenetic tree (1) Amino acid sequence comparison (8) Nucleotide sequence comparison (2) | |
| Mouse | Esr1 | 10 | Amino acid sequence comparison (4) Phylogenetic tree (1) Conserved genome location (synteny) (1) Nucleotide sequence comparison (1) |
- Ai, N., Han, C.R., Zhao, H., Cheng, S.Y., Ge, W. (2024) Disruption of thyroid hormone receptor thrab leads to female infertility in zebrafish. Endocrinology. 165(5):
- Wang, M., Luo, J., Dai, L., Feng, M., Cao, X., Zhang, J., Wan, Y., Yang, X., Wang, Y. (2024) Foxp2 deficiency impairs reproduction by modulating the hypothalamic-pituitary-gonadal axis in zebrafish. Biology of reproduction. 110(5):908-923
- Yinger, R.V., Evangelisto, C.J., Tucker, N.C., Billingsley, J.M., Clair, S.L.S. (2024) β-Estradiol Supplementation Regulates Cholesterol Synthesis Independent of Unsaturated Fat Consumption in Adult Zebrafish. Zebrafish. 21:223230223-230
- Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Shaw, K., Lu, C., Liu, X., Trudeau, V.L. (2023) Arginine vasopressin injection rescues delayed oviposition in cyp19a1b-/- mutant female zebrafish. Frontiers in endocrinology. 14:13086751308675
- Wesselman, H.M., Gatz, A.E., Pfaff, M.R., Arceri, L., Wingert, R.A. (2023) Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney. Cells. 12(4):
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Carril Pardo, C.A., Massoz, L., Dupont, M.A., Bergemann, D., Bourdouxhe, J., Lavergne, A., Tarifeño-Saldivia, E., Helker, C.S., Stainier, D.Y., Peers, B., Voz, M.M., Manfroid, I. (2022) A δ-cell subpopulation with pro-β cell identity contributes to efficient age-independent recovery in a zebrafish diabetes model. eLIFE. 11:
- Chen, X., Zheng, J., Zhang, J., Duan, M., Xu, H., Zhao, W., Yang, Y., Wang, C., Xu, Y. (2022) Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior. The Science of the total environment. 838(Pt 1):155610
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