Genomic Feature
ihb52
- ID
- ZDB-ALT-150424-1
- Name
- ihb52
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one insertion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Yonghua Sun Lab
- Current Source
- China Zebrafish Resource Center (CZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 16: 53714438 - 53714439 (GRCz11) (1) Details
- Nucleotide change
- -/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 1 bp inserted from position 591 to 592 (1)
- Transcript Consequence
- None
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
ATAGCATGTACATGATATATTTCATTCCTCTGCGTACCACCAGAAGGAAGCCTGCGTACCACTAGTGGTACACGTTAGCAGCAGCGAAATCATGCACTGCCCTACACTTTTTTTTCATTTCAAGTAGATGTACTTACCTATCTTACCTTCCGTTTCAAACTTTAACAGTGCTTGGGAAATATTTGAAAAAAAACATATTCACATAAGGATGAATGATTTTTGTATCTCACTGTATGAGTGATTGTTCTGGTGCACTAATGTTATTGTTCCCCATCTCTACAGTCAGCAAATACTGTGAAAAGCTCCGATATGAGCTGGGAAGAGACACTCAGTTCATCACGTCCTACTCTAAAAGTGAGGAGACGCCGCTGGAGGATCTGTACACCGACACGCAGATGGAGCTCCTGAACGACACAGGAGAGAGTTTGGGATATTTACAGAATCTGGACCAACTTTTAGGAGATCATGGAGTCTTCAACCCACAGGCTGAGACTATCTTCA
-/A TCACGGGTGACGCTGGTGTTGGCAAATCAATCATGCTCCAGAAACTGCAGAATCTGTGGTCCAGACGAGAGCTGAAAACCCGCGCCAAATTCTTCTTCAAGTTCAGATGCAGAGCGTTCAGCGCCTTCAAGGAGACGGATGAGATCTCGCTGAAGGATTTAATCTTCAAGCACAACTGCTATCCAGATGGAGATCCAGATAATGAGGTGTTCGCCTACATCTTACGCTTCCCAGAAACTGTGGTGTTCACTTTCGACGGATACGATGAGCTCCAAATGGATTTCGATTTAGATAATGTGCCGGAAACGGTTTCCCCAGAAGAAAAAACACGACCGCTGCTGCTTCTAATGAATCTGCTCTGTGGGAAACTCCTGAAAGGCTCCAGGAAGATTCTGTCAGCAAGAAGTGGCACTGAAATCCAAAGCCGAGTGATTCGGAAGAAAGTGTTCCTGAAGGGATTTGCACCAGAACACCTGAAGAGATATTTAGCTTTGCATTTCC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| nod1ihb52/ihb52 | Homozygous | ♀+/- ♂+/- | Fig. 2  from Hu et al., 2017 | Fig. 1 from Wu et al., 2020 | |
| nod1ihb52/ihb52 | Homozygous | Unknown | Fig. 3 from Cao et al., 2019 | ||
| nod1ihb52/ihb52 (AB/TU) | Homozygous | ♀+/- ♂+/- | |||
| nod1ihb52 | Unknown | Unknown |
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Supplemental Information
- Genotyping protocol
- None
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- Wu, X., Xiong, F., Fang, H., Zhang, J., Chang, M. (2021) Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish. Antibiotics (Basel, Switzerland). 10(7):
- Wu, X.M., Zhang, J., Li, P.W., Hu, Y.W., Cao, L., Ouyang, S., Bi, Y.H., Nie, P., Chang, M.X. (2020) NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS. Journal of immunology (Baltimore, Md. : 1950). 204(8):2216-2231
- Cao, L., Wu, X.M., Nie, P., Chang, M.X. (2019) The negative regulation of piscine CD44c in viral and bacterial infection. Developmental and comparative immunology. 96:135-143
- Wu, X.M., Chen, W.Q., Hu, Y.W., Cao, L., Nie, P., Chang, M.X. (2018) RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Frontiers in immunology. 9:726
- Hu, Y.W., Wu, X.M., Ren, S.S., Cao, L., Nie, P., Chang, M.X. (2017) NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Scientific Reports. 7:2979
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