Genomic Feature
hi2865Tg
- ID
- ZDB-ALT-040929-4
- Name
- hi2865Tg
- Synonyms
-
- hi2865 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the plus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 20: 39345338 - 39345339 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| esco2hi2865Tg/hi2865Tg | Homozygous | ♀+/- ♂+/- | 6 figures  from Percival et al., 2015 | ||
| esco2hi2865Tg/hi2865Tg | Homozygous | Unknown | 2 figures from 2 publications | ||
| esco2hi2865Tg/hi2865Tg (AB) | Homozygous | ♀+/- ♂+/- | Fig. 9 from Thomas et al., 2014 | ||
| esco2hi2865Tg/hi2865Tg (AB/TU) | Homozygous | ♀+/- ♂+/- | 3 figures from Barresi et al., 2010 | Fig. 3 from Barresi et al., 2010 | |
| esco2hi2865Tg/+ (AB) | Heterozygous | Unknown | |||
| esco2hi2865Tg/+ (AB/TU) | Heterozygous | Unknown | |||
| esco2hi2865Tg | Unknown | Unknown | 2 figures from 2 publications | ||
| esco2hi2865Tg (AB/TU) | Unknown | Unknown | |||
| esco2hi2865Tg/hi2865Tg + MO9-tp53 | Complex | 2 figures from Percival et al., 2015 | |||
| tp53zy7/+; esco2hi2865Tg/+ | Complex | Fig 2 from Wang et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Wang, J., Thomas, H.R., Chen, Y., Percival, S.M., Waldrep, S.C., Ramaker, R.C., Thompson, R.G., Cooper, S.J., Chong, Z., Parant, J.M. (2022) Reduced sister chromatid cohesion acts as a tumor penetrance modifier. PLoS Genetics. 18:e1010341
- Percival, S.M., Thomas, H.R., Amsterdam, A., Carroll, A.J., Lees, J.A., Yost, H.J., Parant, J.M. (2015) Variations in sister chromatid cohesion dysfunction in esco2 mutant zebrafish reflects the phenotypic diversity of Roberts Syndrome. Disease models & mechanisms. 8(8):941-55
- Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632
- Xu, B., Lee, K.K., Zhang, L., and Gerton, J.L. (2013) Stimulation of mTORC1 with L-leucine Rescues Defects Associated with Roberts Syndrome. PLoS Genetics. 9(10):e1003857
- Barresi, M.J., Burton, S., Dipietrantonio, K., Amsterdam, A., Hopkins, N., and Karlstrom, R.O. (2010) Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(10):2603-2618
- Milan, D.J., Kim, A.M., Winterfield, J.R., Jones, I.L., Pfeufer, A., Sanna, S., Arking, D.E., Amsterdam, A.H., Sabeh, K.M., Mably, J.D., Rosenbaum, D.S., Peterson, R.T., Chakravarti, A., Kääb, S., Roden, D.M., and MacRae, C.A. (2009) Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization. Circulation. 120(7):553-559
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
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