- Title
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TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress
- Authors
- Jeong, E., Willett, R., Rissone, A., La Spina, M., Puertollano, R.
- Source
- Full text @ Nat. Commun.
TMEM55B interacts with members of the NEDD4-like family of E3 ligases. |
PLEKHM1 interacts with TMEM55B upon NaAsO2 treatment. |
NaAsO2 induces TMEM55B phosphorylation and PLEKHM1 ubiquitination. |
TMEM55B-mediated PLEKHM1 degradation decreases autophagy flux. |
TMEM55B facilitates lysosomal repair by recruiting the ESCRT complex. |
Depletion of TMEM55B reduces cell viability under oxidative stress conditions. |
TMEM55B promotes TFE3 activation through FLCN sequestration. |
Generation and characterization of |