- Title
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Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer
- Authors
- Virtanen, V., Paunu, K., Kukkula, A., Niva, S., Junila, Y., Toriseva, M., Jokilehto, T., Mäkelä, S., Huhtaniemi, R., Poutanen, M., Paatero, I., Sundvall, M.
- Source
- Full text @ Oncogenesis
l-CaD is expressed in PCa cell lines, and |
Loss of l-CaD impairs metastasis and invasion of PCa cells. |
l-CaD expression is upregulated by GR activation promoting growth in organotypic cell culture. |
l-CaD colocalizes with actin in filopodia, and the knockdown of l-CaD downregulates N-cadherin |
l-CaD expression is upregulated during enzalutamide resistance in vivo. |