- Title
-
Neuroprotective Nanoparticles Targeting the Retina: A Polymeric Platform for Ocular Drug Delivery Applications
- Authors
- Colucci, P., Giannaccini, M., Baggiani, M., Kennedy, B.N., Dente, L., Raffa, V., Gabellini, C.
- Source
- Full text @ Pharmaceutics
Nanoparticle characterisation through dynamic light scattering measurements. The hydrodynamic diameter increase of single- (ANP:PNA, green curve) and double- (ANP:PNA:NGF, blue curve) functionalised polyacrylamide nanoparticles resulted in a shift of size distribution compared to naked ANPs (red curve). |
Nanoparticle distribution through retinal layers after intravitreal injection in zebrafish larvae. ( |
Prolonged localisation of nanoparticles at the site of injection. Representative images of 3 days post-fertilisation (dpf) larvae IVT injected with naked Alexa Fluor 594-positive nanoparticles (ANPs) or FITC-labelled PNA-conjugated polyacrylamide nanoparticles (ANP:PNA), analysed at 4 and 24 h post-injection (hpi). As control, zebrafish larvae were IVT injected with DPBS. White asterisk indicates the pronephros. |
NGF exerts its biological activity upon nanoformulation. ( |
Nanoformulated NGF improves visual function impaired by oxidative stress in zebrafish larvae. ( |