- Title
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Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders
- Authors
- Mhalhel, K., Sicari, M., Pansera, L., Chen, J., Levanti, M., Diotel, N., Rastegar, S., Germanà , A., Montalbano, G.
- Source
- Full text @ Cells
Basic skeleton structure of flavonoids and its subclasses. Adapted with permission from [38]. 2021, Giuseppe Montalbano. |
The different biological processes involved in the development of neurodegenerative diseases. |
Schematic drawing of (A) a sagittal section of rodent (left), zebrafish (middle), and human (right) brains with the main neurogenic niches indicated in red. The mammalian brain displays only two main neurogenic niches: the subventricular zone (SVZ) of the lateral ventricles and subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus. The black lines correspond to coronal sections. (B,C): Transversal sections through the brain, marking the major neurogenic niches of the respective species shown in A. In zebrafish, the red dots correspond to slow-cycling progenitors (mainly radial glial cells, type 2), and the green ones to fast-cycling progenitors (mainly neuroblasts, type 3). OB, olfactory bulbs; Ce, cerebellum; D, telencephalic dorsal area; Hyp, hypothalamus; RMS, rostral migratory stream; Dm, dorsomedial zone of the dorsal telencephalon; Dc, central zone of the dorsal telencephalon; Dl, lateral zone of the dorsal telencephalon; Dp, posterior zone of the dorsal telencephalon; Vd, dorsal nucleus of the ventral telencephalon; Vv, ventral nucleus of the ventral telencephalon. This figure is adapted from [296,297]. |