- Title
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PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity
- Authors
- Maskin, C.R., Raman, R., Houvras, Y.
- Source
- Full text @ Sci. Rep.
PPP6C is recurrently mutated in melanoma and has a unique relationship to melanocyte lineage and MITF. ( |
PPP6C disrupts melanocyte differentiation in vivo |
MITF mutation prevents PPP6C-mediated melanocyte differentiation disruption |
MITF promoter activity is reduced under expression of PPP6C(WT) and PPP6C(R264C) on multiple oncogenic backgrounds. ( |
The recurrent |
PPP6C expression affects MITF expression and drug resistance in melanoma. ( |