Fig. 1

B-cell CLL 2-associated athanogene 3 (BAG3) protein. Illustration of human BAG3's structure

Fig. 2

The B-cell CLL 2-associated athanogene (BAG) protein family. Phylogenetic tree illustrating the phylogeny of the BAG protein family within the Eukaryota

Fig. 3

Mammalian B-cell CLL 2-associated athanogene 3 (BAG3). (A) Predicted structures and post-translational modifications (PTMs) of BAG3 orthologues. (B) Amino acids that exhibit a significant gradual shift in their relative distribution using the species are shown in (A). Symbol number indicates the grade of significance with *p < .05 and **p < .01. (C) Phylogenetic tree of mammalian BAG3

Fig. 4

Squamatian B-cell CLL 2-associated athanogene 3 (BAG3). (A) Predicted structures and post-translational modifications (PTMs) of BAG3 orthologues. (B) Amino acids that exhibit a significant gradual shift in their relative distribution and their isoelectric point (IEP) using the species shown in (A). Symbol number indicates the grade of significance with *p < .05 and **p < .01. (C) Phylogenetic tree of squamatian BAG3

Fig. 5

Avian B-cell CLL 2-associated athanogene 3 (BAG3). (A) Predicted structures and post-translational modifications (PTMs) of BAG3 orthologues. (B) Amino acids that exhibit a significant gradual shift in their relative distribution using the species shown in A. Symbol number indicates grade of significance with *p < .05, **p < .01 and ***p < .001. (C) Phylogenetic tree of avian BAG3

Fig. 6

Actinopterygiian B-cell CLL 2-associated athanogene 3 (BAG3). (A) Predicted structures and post-translational modifications (PTMs) of BAG3 orthologues. (B) Amino acids that exhibit a significant gradual shift in their relative distribution using the species shown in (A). Symbol number indicates grade of significance with *p < .05, **p < .01 and ***p < .001. (C) Phylogenetic tree of actinopterygian BAG3

Fig. 7

B-cell CLL 2-associated athanogene 3 (BAG3) LC3 interacting region (LIR) interacting autophagy-related protein 8 (ATG8) paralogues. (A) Comparison of the most preferential interacting ATG8 paralogues for conserved LIR domains within BAG3 orthologues. (B) Illustration of human BAG3's structure with its LIR domains

Fig. 8

Novel implication of B-cell CLL 2-associated athanogene 3 (BAG3) in autophagy. Illustration of a proposed hypothetical model of a ubiquitin independent autophagy mediated by BAG3 as an anchor for autophagosomal structures

Acknowledgments

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