ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Knockdown of pcmt and pcmtl leads to morphological changes and developmental delay. The morphological changes were ranked from mild to severe in 2 dpf larvae [(A–D); trunk curvature and decreased pigmentation) and in 4 dpf larvae (E–H); lack of the swim bladder, body curvature, and strong malformation]. Relative quantification of these phenotypes was performed by observation of the indicated numbers of pcmt/l morphants compared to control and rescue larvae (exogenous expression of pcmt/l via mRNA or Tol2 transgenesis in the morphant background) at 2 dpf (I) and 4 dpf (J). Arrows indicate the internal brain structure showing smaller brain size in the pcmt/l morphant larvae (L) compared to control MO-injected larvae (K).