- Title
-
An Integrated In Silico and In Vivo Approach to Identify Protective Effects of Palonosetron in Cisplatin-Induced Nephrotoxicity
- Authors
- Wakai, E., Suzumura, Y., Ikemura, K., Mizuno, T., Watanabe, M., Takeuchi, K., Nishimura, Y.
- Source
- Full text @ Pharmaceuticals (Basel)
Venn diagrams of genes contained in the gene expression signature associated with cisplatin-induced nephrotoxicity (GES-CIN). Venn diagrams of unique and shared differentially expressed genes in untreated vs. cisplatin-treated mouse kidneys (GSE106993 and GSE130814) or human kidney organoids (GSE145085). Differentially expressed genes were identified using a false discovery rate threshold of 1% ( |
Enrichment of CIN-associated differentially expressed genes in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The 208 genes in the GES-CIN ( |
Maximum values of serum creatinine (Scr) and blood urea nitrogen (BUN) in patients treated for 14 days with cisplatin and either ramosetron or palonosetron. Patients with head and neck cancer ( |
Kaplan–Meier overall survival analysis of patients treated with cisplatin and either ramosetron or palonosetron. Patients with head and neck cancer ( |
Effects of 5-hydroxytryptamine receptor 3 (5-HT3R) antagonists on the survival of zebrafish exposed to cisplatin. Zebrafish (5 days post-fertilization) were treated with the indicated combinations of drugs for 24 h, and survival was assessed. Mean ± SEM of |