- Title
-
Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition
- Authors
- Zhao, W., Cao, L., Ying, H., Zhang, W., Li, D., Zhu, X., Xue, W., Wu, S., Cao, M., Fu, C., Qi, H., Hao, Y., Tang, Y.C., Qin, J., Zhong, T.P., Lin, X., Yu, L., Li, X., Li, L., Wu, D., Pan, W.
- Source
- Full text @ Cell Res.
VEGFA induces vessel regression in EXPRESSION / LABELING:
PHENOTYPE:
|
Vessel regression in CDS2 endothelium-specific knockout mice. |
PI-PIPs metabolism is involved in CDS2-deficient vessel regression. PHENOTYPE:
|
PIP3 exhaustion governs VEGFA-induced regression of CDS2-deficient endothelium. Confocal images ( PHENOTYPE:
|
FOXO1 activation is required for VEGFA-induced vessel regression in mouse retina model. |
FOXO1 activation is required for VEGFA-induced regression in zebrafish PHENOTYPE:
|
PIP3 reduction is mainly caused by PLCγ mediated PIP2 hydrolysis. Representative confocal images ( PHENOTYPE:
|
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