FIGURE SUMMARY
Title

Low Wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

Authors
Benz, F., Wichitnaowarat, V., Lehmann, M., Germano, R.F.V., Mihova, D., Macas, J., Adams, R.H., Taketo, M.M., Guérit, S., Plate, K.H., Vanhollebeke, B., Liebner, S.
Source
Full text @ Elife
Figure 2.

Low Wnt/β-catenin signaling in the adult zebrafish OVLT.

(A) Midline sagittal section of an adult Tg(kdrl:ras-mCherry):Tg(7xTCF-Xia.Siam:EGFP) zebrafish brain. The OVLT-containing area, anatomically-defined following Jeong et al. (2008), is boxed in white. (B) Higher magnification view of (A). The dense and tortuous OVLT endothelium (red) exbibits low Wnt-reporter activity (green) compared to the surrounding vessels. (C) Same as (B) in another individual. Scale bars: (A) 500 μm, (B) and (C) 100 μm; Te, Telencephalon; Me, Mesencephalon; Di, Diencephalon; Ce, Cerebellum; Rh, Rhombencephalon.
Figure 3—figure supplement 1.

Vessel heterogeneity in sensory circumventricular organs (CVOs) involved in water homeostasis.

Plvap/Meca32- and Cldn5-positive ECs in vessels of the SFO, OVLT and PP, demonstrating vessels heterogeneity. Scale bar: left (200 µm), middle (50 µm), right column (20 µm).
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Elife
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