- Title
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New Insights into the Runt Domain of RUNX2 in Melanoma Cell Proliferation and Migration
- Authors
- Deiana, M., Dalle Carbonare, L., Serena, M., Cheri, S., Parolini, F., Gandini, A., Marchetto, G., Innamorati, G., Manfredi, M., Marengo, E., Brandi, J., Cecconi, D., Mori, A., Mina, M.M., Antoniazzi, F., Mottes, M., Tiso, N., Malerba, G., Zipeto, D., Valenti, M.T.
- Source
- Full text @ Cells
Differential migratory ability of wild-type and del-RUNT cells in zebrafish xeno-transplants. Representative images show wild-type (WT, stained in red) and del-RUNT (del-RUNT, stained in green) cells xeno-transplanted in zebrafish embryos 2 days post fertilization (dpf). At day 0 post injection (dpi), transplanted cells are still located in the yolk. At 5 dpi, cells appear more dispersed in the yolk of 7 dpf larvae. At 7 dpi/9 dpf, initial metastases (indicated by white arrowheads) are detectable in WT and, to a lesser extent, in del-RUNT- transplanted larvae. All views are lateral, anterior to the left. Charts on average number of metastases and cell spreading, calculated at 9 dpf in WT (N:22) and del-Runt (N:12) transplanted zebrafish, are shown in (A) and (B), respectively. * p < 0.05. PHENOTYPE:
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