- Title
-
CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss
- Authors
- Teitz, T., Fang, J., Goktug, A.N., Bonga, J.D., Diao, S., Hazlitt, R.A., Iconaru, L., Morfouace, M., Currier, D., Zhou, Y., Umans, R.A., Taylor, M.R., Cheng, C., Min, J., Freeman, B., Peng, J., Roussel, M.F., Kriwacki, R., Guy, R.K., Chen, T., Zuo, J.
- Source
- Full text @ J. Exp. Med.
Kenpaullone protects against cisplatin-induced HC loss in zebrafish lateral lines in vivo. (A–D) Neuromasts (white dots; green arrows) in the zebrafish head were visualized under identical microscopic conditions by staining with 0.005% DASPEI vital dye after treatment for 20 h with medium alone (A), 5 µM cisplatin (B), 5 µM cisplatin and 50 µM benzamil (C), or 5 µM cisplatin and 50 µM kenpaullone. (E) The DASPEI intensity score (mean ± SEM) with various concentrations (micromolar) of kenpaullone (Ken), benzamil, paroxetine, and cisplatin (CIS). Benzamil and paroxetine protect against cisplatin-induced HC loss in zebrafish (Vlasits et al., 2012). The number of zebrafish tested for each condition ranged from three to 13. ** P, < 0.01 and *** P, < 0.001 by one-way ANOVA followed by a Bonferroni comparison. PHENOTYPE:
|