FIGURE SUMMARY
- Title
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Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
- Authors
- Al-Olabi, L., Polubothu, S., Dowsett, K., Andrews, K.A., Stadnik, P., Joseph, A.P., Knox, R., Pittman, A., Clark, G., Baird, W., Bulstrode, N., Glover, M., Gordon, K., Hargrave, D., Huson, S.M., Jacques, T.S., James, G., Kondolf, H., Kangesu, L., Keppler-Noreuil, K.M., Khan, A., Lindhurst, M.J., Lipson, M., Mansour, S., O'Hara, J., Mahon, C., Mosica, A., Moss, C., Murthy, A., Ong, J., Parker, V.E., Rivière, J.B., Sapp, J.C., Sebire, N.J., Shah, R., Sivakumar, B., Thomas, A., Virasami, A., Waelchli, R., Zeng, Z., Biesecker, L.G., Barnacle, A., Topf, M., Semple, R.K., Patton, E.E., Kinsler, V.A.
- Source
- Full text @ Journal of Clin. Invest.
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the effects of BRAF overexpression on tail development in zebrafish larvae. (a) Image of an example of a zebrafish larvae expressing high levels of MAPK signaling, leading to a "stunting" phenotype, as previously described(1, 2) (b) Graph of zebrafish embryos expressing BRAF WT or V600E alleles. Both WT and mutant alleles lead to a stunted phenotype that confounds analysis of the vasculature in those animals, and were excluded from further analysis. |
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Full text @ Journal of Clin. Invest.