- Title
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Differential DNA methylation at conserved non-genic elements and evidence for transgenerational inheritance following developmental exposure to mono(2-ethylhexyl) phthalate and 5-azacytidine in zebrafish
- Authors
- Kamstra, J.H., Sales, L.B., Aleström, P., Legler, J.
- Source
- Full text @ Epigenetics Chromatin
Phenotypic effects after developmental exposure of zebrafish (0-6 days post-fertilization) to mono(2-ethylhexyl) phthalate and 5-azacytidine (5AC). a, b Absolute difference in length of larvae compared to control (error bars represent SEM, *P < 0.05, two-tailed t test, with Bonferroni multiple comparison correction). c Representative images of effects on swim bladder inflation and intestinal development with 5AC exposures at 15 dpf. Arrows indicate swim bladder. d, e Sex ratios in F0 and F1 generations (*P < 0.001, Chi-square) |
Phenotypic effects on swim bladder and gastrointestinal tract in 5-azacytidine (5AC) exposed larvae. Pictures represent individual larvae at 15 dpf. |