FIGURE SUMMARY
Title

Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease

Authors
Fitzmaurice, A.G., Rhodes, S.L., Lulla, A., Murphy, N.P., Lam, H.A., O'Donnell, K.C., Barnhill, L., Casida, J.E., Cockburn, M., Sagasti, A., Stahl, M.C., Maidment, N.T., Ritz, B., and Bronstein, J.M.
Source
Full text @ Proc. Natl. Acad. Sci. USA
Fig. 5

Aminergic neuronal damage in Danio rerio embryos exposed to benomyl. Representative confocal images of zebrafish embryos (A, C, and E) unexposed or (B, D, and F) bathed in 1 μM benomyl from 5 h until 120 h postfertilization are shown. (G) Neuronal counts (A and B) decreased in VMAT2+ anterior and diencephalic clusters of ETvmat2:GFP zebrafish exposed to benomyl (solid bars) but were unaffected in (C and D) Rohon-Beard and (E and F) trigeminal neurons in Tg(isl1[ss]:Gal4-VP16,UAS:EGFP)zf154 zebrafish. (H) Measurement of total fluorescence yielded similar results. Data are expressed as percent relative to vehicle controls (0.01% DMSO). *P < 0.1, **P < 0.05. De, diencephalon; LC, locus coeruleus; OB, olfactory bulb; Te, telencephalon.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA
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