- Title
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The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma formation
- Authors
- Powers, J., Zhao, Y., Lin, S., and McCabe, E.R.
- Source
- Full text @ Dev. Genes Evol.
Single ISH of pitx2a at 48 hpf. a Wild-type control embryo showing expression of pitx2a in the developing brain and 5th branchial arch where pharyngeal tooth development occurs. b dax1 MO2-injected embryo showing unchanged expression of pitx2a. dax1 MO3-injected embryos showed a similar unchanged pitx2a expression pattern. EXPRESSION / LABELING:
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Double ISH of dax1 and eve1. The upper arrow shows purple-staining eve1 expression while the bottom arrow shows red-staining dax1. EXPRESSION / LABELING:
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ISH of eve1 on 48-hpf embryos. a Arrow shows eve1 in the 5th branchial arch in control wild-type embryo. b Circle shows absence of eve1 expression in a dax1 MO-injected wild-type embryo. EXPRESSION / LABELING:
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ISH of DAX1 on human dental tissue specimens. a Normal dental epithelium with the developing enamel organ. Arrows indicate ameloblasts. b Benign ameloblastoma tumor. Arrows indicate purple-stained ameloblasts expressing DAX1. c Malignant ameloblastoma tumor with numerous clusters of purple-stained ameloblasts infiltrating normal dental tissue. |
Unillustrated author statements EXPRESSION / LABELING:
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