Person
Khokhlatchev, Andrei
|
|
Biography and Research Interest
Research Interests: Molecular mechanisms of signal transduction and crosstalk between different signaling pathways.
Education and Training:
M. S. - Moscow State University, Moscow, USSR
Ph.D. - University of Texas Southwestern Medical Center, Dallas, TX
Post-Doctoral - Harvard Medical School, Boston, MA
Positions and Employment:
1984-1991 Research Trainee, Research Fellow, Institute of Bioorganic Chemistry USSR Academy of Science, Moscow, USSR
1991-1993 Research Associate, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
1993-1997 Graduate Student, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
1997- 1998 Postdoctoral Fellow, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
1998-2003 Postdoctoral Fellow and Research Fellow in Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA
2003-2010 Assistant Professor, Department of Pathology, University of Virginia Health System, Charlottesville, VA
March 2010 -present: Senior Scientist, Department of Cell Biology, University of Virginia Health System, Charlottesville, VA
Education and Training:
M. S. - Moscow State University, Moscow, USSR
Ph.D. - University of Texas Southwestern Medical Center, Dallas, TX
Post-Doctoral - Harvard Medical School, Boston, MA
Positions and Employment:
1984-1991 Research Trainee, Research Fellow, Institute of Bioorganic Chemistry USSR Academy of Science, Moscow, USSR
1991-1993 Research Associate, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
1993-1997 Graduate Student, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
1997- 1998 Postdoctoral Fellow, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX
1998-2003 Postdoctoral Fellow and Research Fellow in Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA
2003-2010 Assistant Professor, Department of Pathology, University of Virginia Health System, Charlottesville, VA
March 2010 -present: Senior Scientist, Department of Cell Biology, University of Virginia Health System, Charlottesville, VA
Non-Zebrafish Publications
Here are some of my most relevant publications: Khokhlatchev, A., Canagarajah, B., Wilsbacher, J., Robinson, M., Atkinson, M., Goldsmith, E. J., and Cobb, M. H. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell, 1998, 93:605-615.
Canagarajah, B., Khokhlatchev, A., Cobb, M. H., Goldsmith, E. J. Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell 1997, 90: 859-869.
Khokhlatchev, A., Xu, S., English, J., Wu, P., Schaefer, E., Cobb, M. H. Reconstitution of Mitogen-activated Protein Kinase Phosphorylation Cascades in Bacteria: Efficient synthesis of Active Protein Kinases. J. Biol. Chem., 1997, 272: 11057-11062.
Khokhlatchev A, Xavier R, Rabizadeh S, Nedwidek M, Chen T, Zhang X-f, Seed B, Avruch J. Identification of a novel Ras-regulated proapoptotic pathway. Current Biology, 2002, 12(4) 253-265.
Moshnikova A., Frye J., Shay J. W., Minna J. D., Khokhlatchev A.V. The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway. J. Biol. Chem., 2006, Mar 24, 281(12): 8143-52.
Stieglitz B., Bee C., Schwarz D., Yildiz Ö., Moshnikova A., Khokhlatchev A. and Herrmann C. Novel type of Ras effector interaction established between tumor suppressor NORE1A and Ras switch II. EMBO Journal, 2008 Jul 23;27(14):1995-2005.
Bee C., Moshnikova A., Mellor C., Molloy J., Koryakina Y., Stieglitz B., Khokhlatchev A., and Herrmann C. Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation. J Biol Chem. 2010 May 21; 285(21):16258-66. Epub 2010 Mar 25