Lab
Simon M. Hughes Lab
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Statement of Research Interest
OBJECTIVES:
To understand the formation, growth, maintenance and repair of sarcomeric muscle tissue in vertebrates. We want to understand the ball of 200 cells called a somite assembles itself into a force-generating and force-transmitting tissue. We are also interested to develop reciprocal interaction between studies of the human population and model organisms, and to apply our knowledge to cardiac myogenesis.
ORGANISMS:
We work on zebrafish (mainly) and now want to relate our studies to human genetics and environment by studying datasets such as the UK Biobank. We have interest in training, nutrition, aging, and muscle diseases that impact on people.
METHODOLOGY:
A major aim is to develop improved imaging and tracking systems for understanding cell biological processes in vivo. Muscle cell culture, cell transplantation, high-throughput analyses, transgenesis and genome editing. Standard methods of tissue culture, histology and genetic manipulation and the use of genetically modified animals. We are now expanding into human genetics and epidemiology.
To understand the formation, growth, maintenance and repair of sarcomeric muscle tissue in vertebrates. We want to understand the ball of 200 cells called a somite assembles itself into a force-generating and force-transmitting tissue. We are also interested to develop reciprocal interaction between studies of the human population and model organisms, and to apply our knowledge to cardiac myogenesis.
ORGANISMS:
We work on zebrafish (mainly) and now want to relate our studies to human genetics and environment by studying datasets such as the UK Biobank. We have interest in training, nutrition, aging, and muscle diseases that impact on people.
METHODOLOGY:
A major aim is to develop improved imaging and tracking systems for understanding cell biological processes in vivo. Muscle cell culture, cell transplantation, high-throughput analyses, transgenesis and genome editing. Standard methods of tissue culture, histology and genetic manipulation and the use of genetically modified animals. We are now expanding into human genetics and epidemiology.
Lab Members