Parant Lab

Our broad interests are the impact of genomic instability on human disease. Presently we have two lab focuses: 1) The impact that defects in sister chromatid cohesion has on developmental disease and cancer predisposition; and 2) Understanding the regulation and mechanism of p53 tumor suppression. Much of our research has been facilitated by the development of a high throughput genome editing platform and in vivo live imaging of mitotic defects in mutant zebrafish embryos. Zebrafish is an ideal organism for this research due to the ability to combine powerful genetic approaches and the ability to monitor tumor predisposition.