Lab
Maves Lab
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Statement of Research Interest
Our lab uses the zebrafish model to understand cellular differentiation during cardiac and skeletal muscle development, with the goal of understanding the mechanisms behind congenital heart defects and muscular dystrophy. We are driven by the beauty of the zebrafish embryo as well as the capacity for zebrafish to inform human development and disease. We use Duchenne muscular dystrophy (dmd) zebrafish to identify novel epigenetic drugs that ameliorate DMD as well as to help characterize mechanisms of epigenetic dysregulation in DMD. We also apply our expertise in using CRISPR to study gene knock-outs of new human congenital heart disease loci in zebrafish.
Lab Members
| Louie, Ke’ale Post-Doc | Farr III, G. Hank Research Staff | Reid, Whitaker Research Staff |
- Karuppasamy, M., English, K.G., Henry, C.A., Manzini, M.C., Parant, J.M., Wright, M.A., Ruparelia, A.A., Currie, P.D., Gupta, V.A., Dowling, J.J., Maves, L., Alexander, M.S. (2024) Standardization of zebrafish drug testing parameters for muscle diseases. Disease models & mechanisms. 17(1):
- Hasegawa, E.H., Farr, G.H., Maves, L. (2023) Comparison of Pronase versus Manual Dechorionation of Zebrafish Embryos for Small Molecule Treatments. Journal of developmental biology. 11(2):
- Watson, C.J., Tang, W.J., Rojas, M.F., Fiedler, I.A.K., Morfin Montes de Oca, E., Cronrath, A.R., Callies, L.K., Swearer, A.A., Ahmed, A.R., Sethuraman, V., Addish, S., Farr, G.H., Gómez, A.E., Rai, J., Monstad-Rios, A.T., Gardiner, E.M., Karasik, D., Maves, L., Busse, B., Hsu, Y.H., Kwon, R.Y. (2022) wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. PLoS Genetics. 18:e1010496
- Farr, G.H., Morris, M., Gomez, A., Pham, T., Kilroy, E., Parker, E.U., Said, S., Henry, C., Maves, L. (2020) A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. Skeletal muscle. 10:29
- Maves, L. (2020) Special Issue "Zebrafish-A Model System for Developmental Biology Study". Journal of developmental biology. 8(3)
- Farr, G.H., Imani, K., Pouv, D., Maves, L. (2018) Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects.. Disease models & mechanisms. 11(10):
- Patton, C., Farr, G.H., An, D., Martini, P.G.V., Maves, L. (2018) Lipid Nanoparticle Packaging Is an Effective and Nontoxic mRNA Delivery Platform in Embryonic Zebrafish. Zebrafish. 15(3):217-227
- Row, R.H., Pegg, A., Kinney, B., Farr, G.H., Maves, L., Lowell, S., Wilson, V., Martin, B.L. (2018) BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity. eLIFE. 7
- Goody, M.F., Carter, E.V., Kilroy, E.A., Maves, L., Henry, C.A. (2017) "Muscling" Throughout Life: Integrating Studies of Muscle Development, Homeostasis, and Disease in Zebrafish. Current topics in developmental biology. 124:197-234
- Bouldin, C.M., Manning, A.J., Peng, Y.H., Farr, G.H., Hung, K.L., Dong, A., Kimelman, D. (2015) Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm. Development (Cambridge, England). 142:2499-507
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