Lab
Hyunsook Lee Lab
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Statement of Research Interest
We are interested in the mechanism of initiation and progression of cancer; the molecular mechanism underlying chromosome instability. Multiple systems are used in our laboratory to depending on the specific questions chosen by the lab members: first, we utilize cultured human cell lines for identifying detailed mechanisms using biochemical & cell biological methods; we make mutant mice based on the mechanism we built to understand the physiological cosequence and also to confirm the results in vivo; for visualizing chromosome segregation and study mitosis at the organismal level, we use zebrafish. In summary we try to understand the basis of genetic instability of cancer using multiple systems; cell lines, mouse, and zebrafish. Specific questions are listed below.
1. Chromosome instability in BRCA2-deficient mice
2. Regulatory Mechanisms of BubR1 Spindle assembly checkpoint
3. Understanding mitosis using zebrafish as a model organism
4. Visualizing mitosis in mice (Knockout, Knock-in and transgenic mice) and zebrafish
1. Chromosome instability in BRCA2-deficient mice
2. Regulatory Mechanisms of BubR1 Spindle assembly checkpoint
3. Understanding mitosis using zebrafish as a model organism
4. Visualizing mitosis in mice (Knockout, Knock-in and transgenic mice) and zebrafish
Lab Members
| Choi, Eunhee Post-Doc | Kwon, Misun Post-Doc | Cho, Byuri Graduate Student |
| Choe, Hyerim Graduate Student | Hwang, KwangWoo Graduate Student | Jeon, Hee-Yeon Graduate Student |
| Jeong, Jun-hyeon Graduate Student | Jeong, Kilhoon Graduate Student | Kang, Julki Graduate Student |
| Ko, Eunkyong Graduate Student | Lee, Yookyung Graduate Student | Min, Jaewon Graduate Student |
| Park, Pil-gu Graduate Student | Seong, Junho Graduate Student | Yi, Seonju Graduate Student |