Zhaoxia Sun lab

The Sun lab, based in the Genetics Department of Yale University, focuses on the function of cilia and the etiology of ciliopathies, particularly polycystic kidney disease and primary ciliary dyskinesia. Originally established as a zebrafish lab, the Sun lab has expanded into mouse and cell culture to translate novel findings to clinically more relevant systems. Our interdisciplinary research has taken us into fields that span genetics, chemical genetics, biochemistry, developmental biology, and imaging. More details can be found at https://www.sun-lab-yale.org/. Current key questions include tissue-specific functions of cilia in epithelial cyst formation and interstitial fibrosis in the kidney, the building of motile cilia in zebrafish and the mammalian airway, and chemical-genetic interactions in zebrafish ciliopathy models.