| Phenotype: | leptin-mediated signaling pathway increased occurrence, abnormal |
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| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | leptin-mediated signaling pathway |
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| Synonyms: | adipocytokine signaling pathway, leptin-mediated signalling pathway |
| Definition: | The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. |
| Ontology: | GO: Biological Process [GO:0033210] QuickGO AmiGO |
| Name: | increased occurrence |
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| Synonyms: | increased incidence |
| Definition: | An occurrence which is relatively high. |
| Ontology: | Phenotypic Quality Ontology [PATO:0002051] |