| Phenotype: | synaptic transmission, serotonergic decreased efficacy, abnormal |
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| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | synaptic transmission, serotonergic |
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| Synonyms: | serotonergic synaptic transmission |
| Definition: | The vesicular release of serotonin from a presynapse, across a chemical synapse, the subsequent activation of serotonin receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| Ontology: | GO: Biological Process [GO:0099153] QuickGO AmiGO |
| Name: | decreased efficacy |
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| Synonyms: | |
| Definition: | A decrease in the ability of a process to produce its output. |
| Ontology: | Phenotypic Quality Ontology [PATO:0015003] |