| Phenotype: | phosphatidylinositol 3-kinase/protein kinase B signal transduction decreased occurrence, abnormal |
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| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
|---|---|
| Synonyms: | AKT signal transduction, AKT signaling, AKT signaling cascade, AKT signalling cascade, phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction, PI3K-PKB/Akt pathway, PI3K/Akt signal transduction, PI3K/PKB signal transduction, PKB signal transduction, PKB signaling, PKB signaling cascade, PKB signalling cascade, protein kinase B signal transduction, protein kinase B signaling, protein kinase B signaling cascade, protein kinase B signalling cascade |
| Definition: | An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway. |
| Ontology: | GO: Biological Process [GO:0043491] QuickGO AmiGO |
| Name: | decreased occurrence |
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| Synonyms: | decreased incidence |
| Definition: | An occurrence which is relatively low. |
| Ontology: | Phenotypic Quality Ontology [PATO:0002052] |