ZFIN Phenotype Statement: double-strand break repair via alternative nonhomologous end joining decreased process quality, abnormal

Phenotype:	double-strand break repair via alternative nonhomologous end joining decreased process quality, abnormal
Note:	This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name.

Name:	double-strand break repair via alternative nonhomologous end joining
Synonyms:	A-NHEJ, alt-NHEJ, double-strand break repair via microhomology-mediated end joining, MMEJ
Definition:	An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment.
Ontology:	GO: Biological Process [GO:0097681] QuickGO AmiGO

Name:	decreased process quality
Synonyms:
Definition:	A quality of a process that has a value that is decreased compared to normal or average.
Ontology:	Phenotypic Quality Ontology [PATO:0002302]