| Phenotype: | liver ito cell decreased amount, abnormal |
|---|---|
| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | liver |
|---|---|
| Synonyms: | |
| Definition: | Solid compound organ with three lobes that has many functions including bile production, blood detoxification, the production of critical plasma proteins and clotting factors, complement proteins and the storage of many substances, such as lipids, amino acids, iron, and glycogen. Female fish produce vitellogenins in the liver. |
| Ontology: | Anatomy Ontology [ZFA:0000123] |
| Name: | ito cell |
|---|---|
| Synonyms: | hepatic stellate cell, perisinusoidal cell |
| Definition: | A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype. |
| Ontology: | Anatomy Ontology [ZFA:0009279] |
| Name: | decreased amount |
|---|---|
| Synonyms: | decreased, decreased number, present in fewer numbers in organism, reduced, subnumerary |
| Definition: | An amount which is relatively low. |
| Ontology: | Phenotypic Quality Ontology [PATO:0001997] |