ZFIN Phenotype Statement: whole organism hypoxia-inducible factor-1alpha signaling pathway decreased efficacy, abnormal

Phenotype:	whole organism hypoxia-inducible factor-1alpha signaling pathway decreased efficacy, abnormal
Note:	This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name.

Name:	whole organism
Synonyms:	multi-cellular organism
Definition:	Anatomical structure that is an individual member of Danio rerio.
Ontology:	Anatomy Ontology [ZFA:0001094]

Name:	hypoxia-inducible factor-1alpha signaling pathway
Synonyms:	HIF1alpha pathway, hypoxia-inducible factor signaling, hypoxia-inducible factor-1alpha signalling pathway
Definition:	The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.
Ontology:	GO: Biological Process [GO:0097411] QuickGO AmiGO

Name:	decreased efficacy
Synonyms:
Definition:	A decrease in the ability of a process to produce its output.
Ontology:	Phenotypic Quality Ontology [PATO:0015003]