| Phenotype: | brain nitric oxide mediated signal transduction decreased occurrence, abnormal |
|---|---|
| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | brain |
|---|---|
| Synonyms: | brain structure |
| Definition: | Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system. |
| Ontology: | Anatomy Ontology [ZFA:0000008] |
| Name: | nitric oxide mediated signal transduction |
|---|---|
| Synonyms: | nitric oxide signaling, nitric oxide-mediated signal transduction, NO mediated signal transduction, NO-mediated signal transduction |
| Definition: | An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. |
| Ontology: | GO: Biological Process [GO:0007263] QuickGO AmiGO |
| Name: | decreased occurrence |
|---|---|
| Synonyms: | decreased incidence |
| Definition: | An occurrence which is relatively low. |
| Ontology: | Phenotypic Quality Ontology [PATO:0002052] |