ZFIN Phenotype Statement: cell surface receptor signaling pathway via JAK-STAT increased occurrence, abnormal

Phenotype:	cell surface receptor signaling pathway via JAK-STAT increased occurrence, abnormal
Note:	This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name.

Name:	cell surface receptor signaling pathway via JAK-STAT
Synonyms:	JAK-STAT cascade, JAK-STAT signal transduction, receptor signaling pathway via JAK-STAT
Definition:	A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
Ontology:	GO: Biological Process [GO:0007259] QuickGO AmiGO

Name:	increased occurrence
Synonyms:	increased incidence
Definition:	An occurrence which is relatively high.
Ontology:	Phenotypic Quality Ontology [PATO:0002051]